Table 1. Summary of demographic, clinical features, and laboratory findings of the patients.
Characteristics | Values |
---|---|
Age, yr | 48.9 ± 9.1 (27–76) |
Sex (male:female) | 43:52 |
Duration of clevudine therapy before symptom onset, mon | 14.2 ± 3.9 (5–24) |
Time to nadir of weakness in our seven cases, mon | 8.6 ± 7.5 (3–24) |
Distribution of weakness, No. of patients | |
Bulbar or neck | 13 (13.7) |
Arm | 69 (72.6) |
Proximal arm/distal arm | 66/50 |
Leg | 94 (98.9) |
Proximal leg/distal leg | 86/57 |
Grade of weakness, MRC grade | |
Proximal/distal, arm | 4.5 ± 0.4/4.8 ± 0.4 |
Proximal/distal, leg | 3.7 ± 0.4/4.3 ± 0.5 |
Myalgia, No. of patients | 12 (12.6) |
Recovery from discontinuation of clevudine, wk | 11.8 ± 5.8 (2–36) |
Elevated CK, No. of patients | 93 (97.9) |
Elevated liver enzymes (AST or ALT), No. of patients | 85 (89.5) |
Values are presented as mean ± standard deviation (range) or number (%).
MRC = Medical Research Council, CK = creatine kinase, AST = aspartate aminotransferase, ALT = alanine aminotransferase.