Table 3. Results from ophthalmological examinations in DE patients before and after HSCT.
| Parameters | Pre-HSCT | Post-HSCT | P |
|---|---|---|---|
|
(A) Results for the group of subjects not diagnosed as suffering from DE before HSCT | |||
| OSDI score | 6.4±7.4 4 (0–15) (2–6) | 15.2±14.7 13 (2–56) (7–19) | <0.0001 |
| TFBUT (s) | 13.1±3.0 15 (4–15) (12–15) | 9.2±4.6 8 (1–15) (8–12) | <0.0001 |
| Schirmer test (mm length/5 min) | 30.1±12.1 40 (10–40) (30–40) | 23.3±12.2 20 (2–40) (16–27) | <0.001 |
| Conjunctival staining (van Bijsterveldt score) | 1.15±1.74 0 (0–5) (0–1) | 2.21±2.23 2 (0–8) (1–2) | <0.01 |
| Corneal damage (NEI score) | 0±0 0 (0–0) (0–0) | 1.7±2.1 0 (0–6) (0–3) | <0.0001 |
| MGD score | 1.5±1.1 2.5 (1–4) (2–3) | 6.5±5.5 7.5 (4–14) (7–12) | <0.0001 |
| Conjunctival injection | 0.2±0.2 0.4 (0–1) (0–1) | 0.7±0.8 0.8 (0–2) (0–2) | <0.01 |
|
(B) Results for the group of patients diagnosed as suffering from DE before HSCT | |||
| OSDI score | 9.7±11.7 6 (6–59) (6–8) | 18.2±17.1 15 (6–73) (12–20) | <0.0001 |
| TFBUT (s) | 6.8±2.3 7.5 (1–15) (7–8) | 6.0±2.1 6.1 (1–12) (5–7) | <0.01 |
| Schirmer test (mm length/5 min) | 17.5±13.2 15 (9–40) (10–20) | 15.2±11.2 10 (1–25) (0–12) | <0.01 |
| Conjunctival staining (van Bijsterveldt score) | 2.1±2.5 3 (0–9) (0–3) | 3.6±3.1 3 (0–9) (0–3) | 0.4 |
| Corneal damage (NEI staining score) | 1.9±2.0 2 (0–12) (1–2) | 2.1±2.4 2 (0–12) (2–4) | <0.01 |
| MGD score | 6.5±3.5 7 (3–10) (5–8) | 9.1±7.5 9.5 (5–16) (8–13) | <0.01 |
| Conjunctival injection | 0.5±0.5 0.6 (0–1) (0–1) | 0.9±0.8 0.9 (0–2) (0–2) | <0.01 |
Abbreviations: MGD, Meibomian gland dysfunction; NEI, National Eye Institute; OSDI, Ocular Surface Disease Index; TFBUT, tear film break up time. Values are expressed as mean±SD and median (minimum value– maximum value) (95% confidence interval).