Table 1. Topics associated with PRS at an experiment-wide threshold for significance in primary analysis (left); follow-up analysis of primary associations (right).

Topic	P-value tranche	Primary analysis				Excluding individuals with mood disorder diagnosis
		Coefficient	95% CI		Association P-value	Coefficient	95% CI		Association P-value
Topic 27: Ischemic Heart Disease++	1 × 10−2	0.046	0.022	0.070	0.000221	0.046	0.017	0.074	0.00185
Topic 21: Heart Failure++	1 × 10−4	−0.046	−0.070	−0.021	0.000237	−0.044	−0.072	−0.015	0.00279
Topic 03: Mood Disorders++	1 × 10−2	0.045	0.021	0.070	0.000273	−0.010	−0.039	0.018	0.47953

Abbreviations: CI, confidence interval; PRS, polygenic risk scores.