Table 2. List of top 20 PheWAS codes contributing to topics associated with PRS.

Topic 3: Mood disorders++	Topic 21: Heart failure++	Topic 27: Ischemic heart disease++
Mood disorders	Heart failure	Ischemic Heart Disease
Anxiety phobic and dissociative disorders	Cardiomyopathy	Cardiac conduction disorders
Substance addiction and disorders	Ill-defined descriptions and complications of heart disease	Tobacco use disorder
Pervasive developmental disorders	Cardiac conduction disorders	Pulmonary collapse; interstitial/compensatory emphysema
Schizophrenia and other psychotic disorders	Cardiomegaly	Ill-defined descriptions and complications of heart disease
Adjustment reaction	Ischemic Heart Disease	Hyperplasia of prostate
Tobacco use disorder	Pulmonary congestion and hypostasis	Congenital musculoskeletal anomalies
Back pain	Renal failure	Hypotension
Malaise and fatigue	Pleurisy; pleural effusion	Cardiomegaly
Other headache syndromes	Pulmonary collapse; interstitial/compensatory emphysema	Vertiginous syndromes and other disorders of vestibular system
Sleep disorders	Other forms of chronic heart disease	Pleurisy; pleural effusion
Abdominal pain	Heart valve disorders	Syncope and collapse
Acute upper respiratory infections	Disorders of fluid electrolyte and acid-base balance	Symptoms/disorders of the urinary system
Superficial cellulitis and abscess	Other anemias	Benign neoplasm of colon
Constipation	Hypotension	Overweight
Alcohol-related disorders	Diabetes mellitus	Sleep disorders
Disorders of sweat glands	Pneumonia	Malaise and fatigue
Other nutritional deficiency	Shock	Varicose veins
Neurological disorders due to brain damage	Symptoms involving skin and other integumentary tissue	Other dermatoses
Delirium dementia and amnestic disorders	Syncope and collapse	Heart valve disorders

Abbreviation: PRS, polygenic risk scores.