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. 2017 Sep 19;7(9):e1233. doi: 10.1038/tp.2017.205

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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hBDNF^Val66Met genotype and history of CORT treatment regulate immobility in the Forced-Swim Test (FST). (a) A main effect of genotype was detected at baseline for immobility, where hBDNF^Met/Met mice were immobile for significantly longer than hBDNF^Val/Val mice. An interaction between genotype and CORT treatment was also observed, where the hBDNF^Val/Val mice were most susceptible to the effects of CORT on immobility. (b) No main effect or interaction was detected for average latency to immobility. (c–e) An analysis of immobility as a time-course confirmed the selective effect of CORT on this genotype group. All data are presented as mean±s.e.m.; ***P<0.001, ****P<0.0001. Per group, n=23–40.