Table 1.

Algorithm for symptom alert triggers in the Pain Buddy symptom diary.

Symptom	Ratings
MSAS 7–12
Overall pain rating	≥7.5
Pain	≥A medium amount (Frequency) AND ≥A medium amount (Severity) AND ≥A medium amount (Bothersome/Distressing)
Tired	Three consecutive entries of:
	Almost all the time (Frequency) AND Very tired (Severity) AND Very much (Bothersome)
Itching	Three consecutive entries of:
	Almost all the time (Frequency) AND Very itchy (Severity) AND Very much (Bothersome/Distressing)
Vomiting	Three consecutive entries of:
	≥A medium amount (Frequency) AND ≥A medium amount (Bothersome/Distressing)
Sleep	Five consecutive entries of:
	≥A medium amount (Bothersome/Distressing)
Feeling Sad	Five consecutive entries of:
	≥A medium amount (Frequency) AND ≥A medium amount (Severity) AND ≥A medium amount (Bothersome/Distressing)
Worried	Five consecutive entries of:
	≥A medium amount (Frequency) AND
	Very worried (Severity) AND ≥A medium amount (Bothersome/Distressing)
MSAS 8–18
Overall pain rating	≥7.5
Pain	≥A lot (Frequency) AND ≥Moderate (Severity) AND ≥Somewhat (Bothersome/Distressing)
Drowsiness, Difficulty Swallowing	≥A lot (Frequency) AND ≥Severe (Severity) AND ≥Quite a Bit (Bothersome/Distressing)
Problems with Urination	≥A lot (Frequency) AND ≥Severe (Severity) AND ≥Somewhat (Bothersome/Distressing)
Shortness of Breath	≥Sometimes (Frequency) AND ≥Moderately (Severity) AND
	≥Somewhat (Bothersome/Distressing)
Cough	Three consecutive entries of:
	≥A lot (Frequency) AND ≥Severe (Severity) AND ≥Somewhat (Bothersome/Distressing)
Numbness	Three consecutive entries of:
	Almost Always (Frequency) AND Very Severe (Severity) AND
	≥Quite a bit (Bothersome/Distressing)
Vomiting, Diarrhea, Dizziness, Itching	Three consecutive entries of:
	≥A lot (Frequency) AND ≥Severe (Severity) AND ≥Quite a Bit (Bothersome/Distressing)
Nausea	Three consecutive entries of:
	≥A lot (Frequency) AND ≥Moderate (Severity) AND ≥Quite a Bit (Bothersome/Distressing)
Constipation	Three consecutive entries of:
	≥Moderately (Severity) AND ≥Quite a Bit (Bothersome/Distressing)
Headache	Three consecutive entries of:
	≥Sometimes (Frequency) AND ≥Moderately (Severity) AND
	≥Somewhat (Bothersome/Distressing)
Mouth Sores	Three consecutive entries of:
	≥Moderately (Severity) AND ≥Somewhat (Bothersome/Distressing)
Lack of Energy	Five consecutive entries of:
	≥Sometimes (Frequency) AND ≥Moderately (Severity) AND
	≥Somewhat (Bothersome/Distressing)
Nervousness	Five consecutive entries of:
	≥A lot (Frequency) AND Very Severe (Severity) AND ≥Quite a Bit (Bothersome/Distressing)
Feelings of Sadness	Five consecutive entries of:
	Almost Always (Frequency) AND Very Severe (Severity) AND Very Much (Bothersome/Distressing)
Sweats	Five consecutive entries of:
	Almost Always (Frequency) AND Very Severe (Severity) AND ≥Quite a Bit (Bothersome/Distressing)
Swelling in Arms or Legs	Five consecutive entries of:
	Very Severe (Severity) AND Very Much (Bothersome/Distressing)
Changes in Skin	Five consecutive entries of:
	Very Severe (Severity) AND ≥Quite a Bit (Bothersome/Distressing)