Table I.
Comparison of clinical characteristics between intrahepatic cholangiocarcinoma patients with and without cirrhosis.
| Characteristics | With cirrhosis, n (%) (n=302) | Without cirrhosis, n (%) (n=1,010) | P-value |
|---|---|---|---|
| Age (years) | <0.001 | ||
| Mean ± standard deviation | 51.65±10.05 | 54.80±11.07 | |
| Gender | <0.001 | ||
| Male | 270 (89.4) | 626 (62.0) | |
| Female | 32 (10.6) | 384 (38.0) | |
| Symptoms | <0.001 | ||
| No | 155 (51.3) | 344 (34.1) | |
| Yes | 147 (48.7) | 666 (65.9) | |
| HBsAg positivity | 272 (90.1) | 326 (32.3) | <0.001 |
| Alcoholic | 59 (19.5) | 131 (13.0) | 0.004 |
| Schistosomiasis | 7 (2.3) | 64 (6.3) | 0.007 |
| Cholelithiasis | 30 (9.9) | 224 (22.2) | <0.001 |
| Elevated AFP level | 119 (39.4) | 129 (12.8) | <0.001 |
| Elevated CA19-9 and/or CEA level | 143 (47.4) | 633 (62.7) | <0.001 |
| Albumin (g/l) | 0.164 | ||
| Mean ± standard deviation | 41.53±3.97 | 41.91±4.29 | |
| Bilirubin (µmol/l) | 0.016 | ||
| ≤20 | 243 (80.5) | 870 (86.1) | |
| >20 | 59 (19.5) | 140 (13.9) | |
| ALT(U/l) | 0.001 | ||
| ≤42 | 197 (65.2) | 759 (75.1) | |
| >42 | 105 (34.8) | 251 (24.9) |
AFP, α-fetoprotein; CA19-9, carbohydrate antigen 19-9; CEA, carcinoembryonic antigen; HBsAg, hepatitis B surface antigen; ALT, alanine aminotransferase.