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. 2017 Aug 22;14(4):3577–3582. doi: 10.3892/etm.2017.5001

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Copyright: © Yu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 6. — mRNA expression levels of Hedgehog (Hh) pathway components during quiescent hepatic stellate cell (HSC) activation. Quiescent HSCs were stimulated with transforming growth factor (TGF)-β1 (5 µg/l) for 12 h. mRNA expression levels of Shh, Smo, and Gli2 were significantly higher than in the control group. Treatment with UA (40 µM) for 30 min and then stimulation with TGF-β1 (5 µg/l) inhibited mRNA expression of these genes. Ursolic acid (UA) and diphenyleneiodonium chloride (DPI) had comparable effects. *P<0.05 vs. the control group; **P<0.01 vs. the control group; ^##P<0.01 vs. the TGF-β1 group.