Figure 3.

Clinical implication of CD19⁺CD24^hiCD38^hi Bregs in patients with HT. (A) The decrease in ratio of CD19⁺CD24^hiCD38^hi Bregs to lymphocytes (CD19⁺CD24^hiCD38^hi/L) significantly increases the morbidity associated with DM; HT patients with decreased CD19⁺CD24^hiCD38^hi/L (n=20) had significantly higher levels of TCH and LDL-C, compared with those without (n=64). The decrease in the ratio of CD19⁺CD24^hiCD38^hi Bregs to CD19⁺ lymphocytes (CD19⁺CD24^hiCD38^hi/CD19⁺) was associated with high (B) TCH and (C) LDL-C levels. *P<0.05 vs. Not decr. Data is presented as mean ± standard deviation. Bregs, regulatory B cells; HT, Hashimoto's thyroiditis; CD19⁺CD24^hiCD38^hi/L, ratio of CD19⁺CD24^hiCD38^hi Bregs to lymphocytes; DM, diabetes mellitus; HDL-C, high-density lipoprotein cholesterol; IGR, impaired glucose regulation; LDL-C, low-density lipoprotein cholesterol; TCH, total cholesterol; TG, triglyceride.