Table I.
Demographic characteristics and laboratory measurements of patients with HT and control groups.
| Characteristics and measurements | HT group (n=52) | Control group (n=35) | P-value |
|---|---|---|---|
| Age, years | 42.2±14.7 | 40.6±16.9 | NS |
| Waist circumference, cm | 76.4±9.4 | 77.1±8.7 | NS |
| Hip circumference, cm | 94.6±7.3 | 93.5±4.1 | NS |
| Waist-hip ratio | 0.9±0.3 | 0.9±0.3 | NS |
| Systolic blood pressure, mmHg | 122.5±8.8 | 119.7±22.9 | NS |
| Diastolic blood pressure, mmHg | 74.5±5.3 | 76.2±5.4 | NS |
| Body mass index, kg/m2 | 22.9±3.7 | 22.9±3.2 | NS |
| TCH, mmol/l | 4.8±1.2 | 4.5±0.9 | NS |
| TG, mmol/l | 1.4±0.8 | 1.1±0.8 | NS |
| HLD-C, mmol/l | 1.5±0.4 | 1.3±0.6 | NS |
| LDL-C, mmol/l | 3.3±1.3 | 3.0±0.7 | NS |
| FPG, mmol/l | 5.6±2.0 | 4.7±0.6 | NS |
| Fasting c-peptide, ng/ml | 1.7±1.8 | 1.2±0.7 | NS |
| Fasting insulin, mU/l | 12.4±16.8 | 11.6±14.1 | NS |
| 30 min plasma glucose, mmol/l | 8.6±2.1 | 7.7±1.7 | NS |
| 30 min c-peptide, ng/ml | 6.8±2.9 | 5.7±1.8 | 0.039 |
| 30 min insulin, mU/l | 80.8±21.6 | 47.9±19.3 | <0.001 |
| 120 min plasma glucose, mmol/l | 7.6±3.8 | 7.4±2.8 | NS |
| 120 min c-peptide, ng/ml | 6.1±4.1 | 5.7±2.8 | NS |
| 120 min insulin, mU/l | 71.2±3. | 28.9±36.0 | <0.001 |
| GADA, % | 0.0 | 0.0 | NS |
| IAA, % | 0.0 | 0.0 | NS |
| ICA, % | 0.0 | 0.0 | NS |
| IGR, % | 39.1 | 30.8 | NS |
| HOMA-IR | 2.5±1.9 | 1.8±1.0 | NS |
| HOMA-β | 132.4±95.7 | 187.1±153.6 | NS |
| ΔI30/ΔG30 | 20.3±18.5 | 17.3±13.2 | NS |
| Matsuda Index | 6.1±4.8 | 6.9±3.2 | NS |
| InsAUC30/GluAUC30 | 45.3±31.2 | 32.2±14.1 | 0.015 |
| InsAUC120/GluAUC120 | 61.9±38.5 | 45.1±22.2 | 0.047 |
| DI | 70.6±39.4 | 108.6±78.6 | 0.002 |
| DI30 | 216.9±161.4 | 196.3±89.1 | NS |
| DI120 | 284.5±127.6 | 260.0±107.8 | NS |
Data is presented as mean ± standard deviation. FPG, fasting plasma glucose; DI, disposition index; GADA, glutamic acid decarboxylase antibodies; HDL-C, high-density lipoprotein cholesterol; HOMA-β, homeostasis model assessment of β cell function; HOMA-IR, homeostasis model assessment of insulin resistance; HT, Hashimoto's thyroiditis; IAA, insulin autoantibodies; ICA, islet cell antibodies; IGR, impaired glucose regulation; InsAUC; area under curve of blood insulin level; GluAUC, area under curve of plasma glucose level; LDL-C, low-density lipoprotein cholesterol; NS, not significant; TCH, total cholesterol; TG, triglyceride; ΔI30/ΔG30, insulin/glucose ratio responses over the first 30 min during the oral glucose tolerance test.