Figure 1.

EGOT is downregulated in glioma and differentially expressed in glioma cell lines. (A) Relative transcription levels of EGOT in 50 cases of clinical glioma tissues as well as their matched adjacent non-cancerous tissues were evaluated via reverse transcription-quantitative polymerase chain reaction analysis. (B) Transcription levels of EGOT were analyzed in five cell lines, including the normal glial HEB cells and four glioma cell lines: A172, U251, U87 and SHG44. Glioma cell lines exhibited significantly lower transcription levels of EGOT than the normal HEB cells and among the four glioma cell lines, highly aggressive U251 and U87 cells exhibited the lowest levels of EGOT. All data are expressed as the mean ± standard deviation. *P<0.05 vs. HEB; **P<0.01. EGOT, eosinophil granule ontogeny transcript.