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. 2017 Sep 18;82(3):385–395. doi: 10.1002/ana.25017

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© 2017 The Authors Annals of Neurology published by Wiley Periodicals, Inc. on behalf of American Neurological Association

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Characterization of a tetrodotoxin (TTX)‐sensitive persistent inward current in ClC muscle. (A) The voltage protocol used to identify persistent inward currents (PICs). From a holding potential of −85mV, fibers were depolarized to −10mV at a rate of 10mV/s. (B) The current trace generated by the ramp depolarization in normal K⁺ solution with 20μM nifedipine. A fit line (thin) is drawn using the first 0.5 seconds of the raw trace, representing the leak current. Deviations from the leak current/fit line in the negative direction are consistent with activation of a PIC. (C) Shown is a trace generated by subtracting the leak trace shown in B and plotting against voltage. (D) Plot of leak‐subtracted PIC in K⁺‐free solutions (−TTX). The PIC was blocked by the addition of 1μM TTX to the external solution (+TTX).