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. 2017 Oct 6;9:109. doi: 10.1186/s13148-017-0415-6

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — KIBRA “CCGG” methylation within CpG I in ccRCC samples. a Methylation patterns of “CCGG”-motifs within CpG I in control (Ctrl) and ccRCC samples. Each line represents one “CCGG”-motif within CpG I. Filled circles indicate methylated, open circles indicate unmethylated “CCGG”-motifs. Differences of methylation between the control (12/144 [8.3%]) and ccRCC (14/72 [19.4%]) group were significant (p = 0.039). Analysis revealed significantly decreased mRNA KIBRA expression levels for ccRCC samples in b real-time PCR and c western blot analyses. ***p < 0.001; m median