Table 1.
Proportion of patients with disease transformation according to baseline characteristics
| Sample size | Richter’s syndrome | Prolymphocytic leukemia | All other patients | p-value† | |
|---|---|---|---|---|---|
|
| |||||
| (n=34) | (n=10) | (n=477) | |||
| No. (%) | No. (%) | No. (%) | |||
| Treatment arm* | |||||
| F | 188 | 14 (7) | 3 (2) | 171 (91) | |
| C | 191 | 9 (5) | 4 (2) | 178 (93) | |
| F+C | 142 | 11 (8) | 3 (2) | 128 (90) | 0.78 |
| Rai stage | |||||
| I/II | 315 | 19 (6) | 2 (1) | 294 (93) | |
| III/IV | 206 | 15 (7) | 8 (4) | 183 (89) | 0.02 |
| Gender | |||||
| Male | 359 | 26 (7) | 5 (1) | 328 (91) | 0.28 |
| Female | 162 | 8 (5) | 5 (3) | 149 (92) | |
| Mean age at study entry (in years) | 62 | 59 | 63 | 0.55 | |
*
F=fludarabine; C=chlorambucil; F+C= fludarabine + chlorambucil
†
The first p-value has 4 df; the remainder have 2 df.