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. Author manuscript; available in PMC: 2017 Oct 13.
Published in final edited form as: Nature. 2017 Mar 29;544(7648):110–114. doi: 10.1038/nature21711

Extended Data Figure 1. Comparison of conventional and strong fixation conditions for Hi-C.

Extended Data Figure 1

Pc(s) of contact probability over genomic separation has similar shape under conventional (1% of formaldehyde for 10 minutes) and strong (2% of formaldehyde for 15 minutes) fixation conditions. Pc(s) plot for the CH12-LX cell line is constructed using previously published in situ Hi-C data8 and is normalized to integrate to 1.