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. Author manuscript; available in PMC: 2017 Oct 13.
Published in final edited form as: Nature. 2017 Mar 29;544(7648):110–114. doi: 10.1038/nature21711

Figure 3. Chromatin reorganization during oocyte maturation.

Figure 3

a, Immature (Non-Surrounded Nucleolus, NSN) and mature (Surrounded Nucleolus, SN) oocytes stained with Hoechst (magenta). Scale bar, 25 μm. Images were adjusted in brightness/contrast settings in the individual channels using ImageJ. b–d, Comparison of average TAD strength (b), loop strength (c) and compartment strength (d) in NSN and SN oocytes with Hoechst staining (n(NSN)=15, n(SN)=30). Error bars in (d) show standard deviation, obtained by bootstrapping. e, Pc(s) in data from combined NSN and SN oocytes, scored by Hoechst staining. f–g, Pc(s) in single Hoechst-stained NSN (f, n=9) and SN oocytes (g, n=27) with >30K total contacts.