Table 3.
IVUS
| Variables | Overall (n = 71) | Group 1 (n = 40) | Group 2 (n = 31) | p value |
|---|---|---|---|---|
| QCA analysis | ||||
| Reference diameter, mm | 2.7 ± 0.7 | 2.6 ± 0.6 | 2.8 ± 0.8 | 0.186 |
| Diameter stenosis, % | 21.9 ± 12.9 | 23.6 ± 13.2 | 19.8 ± 12.2 | 0.078 |
| Plaque location, n (%) | ||||
| LAD | 51 (33.3) | 27 (32.9) | 24 (33.8) | 0.360 |
| LC | 54 (35.3) | 28 (34.2) | 26 (36.6) | 0.177 |
| RCA | 48 (31.4) | 27 (32.9) | 21 (29.6) | 0.983 |
| Diameter stenosis, % | ||||
| LAD | 22.1 ± 12.5 | 23.6 ± 14.0 | 20.4 ± 10.6 | 0.361 |
| LC | 23.3 ± 16.8 | 24.8 ± 14.0 | 20.2 ± 13.1 | 0.219 |
| RCA | 21.1 ± 11.7 | 20.9 ± 11.1 | 21.3 ± 12.6 | 0.906 |
| Gray-scale IVUS analysis | ||||
| EEM CSA, mm2 | 14.0 ± 4.9 | 14.0 ± 4.8 | 14.1 ± 5.0 | 0.953 |
| Lumen CSA, mm2 | 7.8 ± 3.7 | 7.5 ± 3.4 | 8.2 ± 3.9 | 0.284 |
| Plaque CSA, mm2 | 6.2 ± 2.5 | 6.5 ± 2.6 | 5.8 ± 2.4 | 0.109 |
| Remodeling index | 0.81 ± 0.22 | 0.83 ± 0.25 | 0.78 ± 0.20 | 0.181 |
| EEM volume, mm3 | 140.3 ± 48.9 | 139.9 ± 48.1 | 140.7 ± 50.0 | 0.953 |
| Lumen volume, mm3 | 78.4 ± 36.5 | 74.9 ± 34.3 | 82.4 ± 38.8 | 0.282 |
| Plaque volume, mm3 | 61.9 ± 25.2 | 65.0 ± 25.7 | 58.3 ± 24.3 | 0.109 |
| Plaque volume, % | 45.0 ± 12.4 | 47.2 ± 11.6 | 42.41 ± 12.9 | 0.070 |
| iMap IVUS analysis | ||||
| Fibrous volume, mm3 (%) | 38.4 ± 14.1 (64.6 ± 12.8) | 40.2 ± 13.2 (63.6 ± 13.4) | 36.3 ± 14.8 (65.6 ± 11.9) | 0.027 (0.106) |
| Lipid volume, mm3 (%) | 7.1 ± 4.4 (10.9 ± 3.5) | 7.5 ± 4.6 (10.8 ± 3.4) | 6.7 ± 4.2 (10.9 ± 3.7) | 0.281 (0.421) |
| Necrotic volume, mm3 (%) | 15.4 ± 12.2 (22.3 ± 9.6) | 16.7 ± 12.4 (23.1 ± 10.1) | 13.8 ± 11.8 (21.4 ± 8.9) | 0.102 (0.109) |
| Calcified volume, mm3 (%) | 1.5 ± 1.7 (2.3 ± 1.9) | 1.9 ± 2.0 (2.5 ± 2.0) | 1.1 ± 1.1 (2.0 ± 1.7) | 0.063 (0.251) |
Values are mean ± SD (%). Group 1: ≥ 60 mL/min/1.73 m2, Group 2: < 60 mL/min/1.73 m2. p values for Group 1 vs. Group 2. EEM CSA, lumen CSA, and plaque CSA were measured at the minimum lumen CSA site in each plaque
IVUS intravascular ultrasound; QCA quantitative coronary angiography; LAD left anterior descending artery; LC left circumflex artery; RCA right coronary artery; EEM external elastic membrane; CSA cross-sectional area