Table 3.
Alpha1-adrenergic antagonists with their side-effect profiles and cost
| Drug | Uroselective | Hypotension | PDE-5i Worsen Hypotension |
Ejaculatory Dysfunction |
Cost per Month |
|---|---|---|---|---|---|
| Terazosin | No | ↑↑↑ | Yes | No | $48 |
| Doxazosin | No | ↑↑↑ | Yes | No | $118 (ER) $43 (IR, generic) $107 (IR, Cardura) |
| Tamsulosin | Yes | — | No | Yes | $126 (generic) $226 (Flomax) |
| Alfuzosin | Yes | ↑ | No | No | $126 (generic) $690 (Uroxatral) |
| Silodosin | Yes | — | No | Yes | $227 |
Abbreviations: ER, extended release; IR, immediate release; PDE-5i, phosphodiesterase-5 inhibitors.