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. Author manuscript; available in PMC: 2018 Jun 1.
Published in final edited form as: Clin Genet. 2017 Feb 22;91(6):913–917. doi: 10.1111/cge.12930

Figure 2. Segregation, protein location and conservation of IARS variants.

Figure 2

A: Pedigree showing the segregation of IARS variants detected. The two unaffected sisters did not carry both variants. B: IARS protein domains and location of the missense substitutions. C: Conservation down to yeast and previously described catalytic active site [13] and tRNA binding site [12].