Table 4.
Biochemical analysis of the vagina after MatriStem implantation modeling transabdominal insertion (MatriStem TA, n=8) or transvaginal insertion (MatriStem TV, n=8) as compared to historical data for Sham [14]. Results are expressed as mean ± standard deviation. Post hoc P values represent comparisons between groups.
| Biochemistry analysis | ||||
|---|---|---|---|---|
|
|
||||
| Collagen (% of dry weight) |
Elastin (% of dry weight) |
GAG (% of dry weight) |
Col III/I ratio | |
| Sham | 48.3 ± 8.6 | 16.5 ± 4.4 | 1.35 ± 0.33 | 0.20 ± 0.05 |
| MatriStem TA | 43.6 ± 4.6 | 18.5 ± 4.8 | 1.64 ± 0.30 | 0.24 ± 0.04 |
| MatriStem TV | 37.7 ± 7.8a | 16.4 ± 3.3 | 1.45 ± 0.18 | 0.25 ± 0.04a |
|
| ||||
| P* | 0.016 | 0.534 | 0.107 | 0.036 |
|
| ||||
| Post hoc P | ||||
|
| ||||
| TA vs. Sham | 0.304 | 0.527 | 0.068 | 0.088 |
|
| ||||
| TV vs. Sham | 0.008 | 0.989 | 0.675 | 0.038 |
*
indicates the overall comparison among the groups
a
indicates p<0.05 compared with Sham