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Effect of GSPE on Aβ40 oligomerization. IC50 values are reported for Aβ40 dimer through hexamer for each GSPE fraction tested. Values were determined by densitometry of cross-linked oligomer bands on silver stained gels.
| Aβ40 Oligomer | GSPE Fraction IC50 (μM) | |||
|---|---|---|---|---|
|
| ||||
| Mixture | Monomer | Dimer | Oligomer | |
| Dimer | 49 | 48 | 40 | 27 |
| Trimer | 40 | 40 | 34 | 26 |
| Tetramer | 33 | 36 | 34 | 23 |
| Pentamer | 41 | 26 | 34 | 26 |
| Hexamer | 8 | 8 | 16 | 7 |
