TABLE 2.

Local Recurrence Interval Flexible Parametric Survival Model Multivariable Analysis Results for all Patients (Excluding Those With Neoadjuvant Chemotherapy)

Covariate	HR*	95% CI	P
Surgical type at 5 years
Mastectomy	1 (Ref. cat.)	—	—
BCS (unadjusted)	5.33	4.15 to 6.85	<0.001
BCS (adjusted)	5.00	3.57 to 23.69	<0.001
Surgical type at 10 years
Mastectomy	1 (Ref. cat.)	—	—
BCS (unadjusted)	11.68	9.05 to 15.07	<0.001
BCS (adjusted)	6.06	1.29 to 28.40	0.022
Age at diagnosis, y, (continuous)	1.02	0.95 to 1.09	0.662
Maximum overall (invasive + in situ) tumor size, (mm) (continuous)	1.42	0.78 to 2.58	0.253
Focality
Localized	1 (Ref. cat.)	—	—
Multifocal	1.15	0.58 to 2.30	0.688
N stage
N0	1 (Ref. cat.)	—	—
N1	1.18	0.71 to 1.96	0.527
Histological grade
1	1 (Ref. cat.)	—	—
2	1.63	0.38 to 7.02	0.514
3	1.42	0.33 to 6.16	0.636
ER status
Negative	1 (Ref. cat.)	—	—
Positive	0.64	0.28 to 1.48	0.297
HER2 status
Negative	1 (Ref. cat.)	—	—
Positive	1.33	0.77 to 2.30	0.306
Adjuvant radiotherapy
No/unknown	1 (Ref. cat.)	—	—
Yes	0.32	0.16 to 0.64	0.001
Adjuvant hormone therapy
No/unknown	1 (Ref. cat.)	—	—
Yes	0.64	0.28 to 1.47	0.295
Surgical margins, mm
0	1 (Ref. cat.)	—	—
≥0 to <1	0.74	0.26 to 2.14	0.579
≥1 to ≤5	0.93	0.40 to 2.18	0.871
>5	0.89	0.36 to 2.22	0.803

CI indicates confidence interval; ER, estrogen receptor; HER2, human epidermal growth factor receptor 2; HR, hazard ratio.

^*Unless otherwise stated, HR presented for the multivariable (adjusted) model.