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. Author manuscript; available in PMC: 2017 Oct 13.
Published in final edited form as: Nat Cell Biol. 2017 Aug 21;19(9):1071–1080. doi: 10.1038/ncb3594

Figure 3. Cohesin activity is required for mitotic compaction and cis-looping.

Figure 3

a) Hi-C data collected from M phase cells following disruption of coHesin using the scc1-73 allele (MH). Chromosomes XIII to XVI are shown as representative of the whole genome. Contact maps were assembled from two independent experiments.

b) Log2 ratio of –cohesin MH dataset over wt M dataset (MH/M), displayed in 3a and 1c, respectively.

c) Contact probability (P(s)) for wt metaphase M and cohesin depleted metaphase cells MH phase cells and G1 cells averaged over all chromosomes. The P(s) from each of the two independent experiments for each condition are shown.

d) Goodness-of-fit for models with variable cis-loop coverage (horizontal axis) and number (vertical axis). Best fitting parameter region indicated by arrows emanating from MH.