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. Author manuscript; available in PMC: 2017 Oct 13.
Published in final edited form as: Science. 2016 Nov 11;354(6313):765–768. doi: 10.1126/science.aaf7532

Figure 1. AIM2 inflammasome deficiency protects mice from SBI induced small intestine syndrome.

Figure 1

(A–D) WT mice were cohoused with Casp1(11)−/−, Casp1−/−, Asc−/− or Aim2−/− mice for two weeks and then exposed to 14.2 Gy of subtotal-body irradiation (SBI). Kaplan-Meier survival analysis of Casp1(11)−/− mice (A), Casp1−/− mice (B), Asc−/− mice (C), Aim2−/− (D) mice and their cohabitated WT mice was performed. Each figure represents the pooled data from two to three independent experiments. The total number of mice in each group and the p value by log-rank comparison are indicated on the plots. (E) Representative pictures of H&E staining of the jejunum from Aim2−/− mice and their cohabitated WT mice at day 0 and day 3.5 after 14.2 Gy of SBI. Scale bar=100 μm.