Table 1. Association between expression of HSP10 and c-PARP proteins and astrocytoma clinical pathological features (n = 103).
| Characteristics (n) | HSP10 | c-PARP | HSP10/c-PARP# | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Low (%) | High (%) | P-value | Low (%) | High (%) | P-value | N- (%) | P+ (%) | P-value | |
| Age1 | |||||||||
| < 43 (n = 44) | 28(63.6) | 16(36.4) | 0.431 | 31(70.5) | 13(29.5) | 0.642 | 34 (77.3) | 10 (22.7) | 0.055 |
| ≥43 (n = 59) | 33(55.9) | 26(44.1) | 44(74.6) | 15(25.4) | 35(59.3) | 24 (40.7) | |||
| Gender | |||||||||
| Female (n = 54) | 33 (61.1) | 21(38.9) | 0.682 | 36 (66.7) | 18 (33.3) | 0.141 | 37 (68.5) | 17 (31.5) | 0.729 |
| Male (n = 49) | 28 (57.1) | 21(42.9) | 39(79.6) | 10 (20.4) | 32(65.3) | 17(34.7) | |||
| Tumor size2 | |||||||||
| <5.0 cm (n = 58) | 30 (51.7) | 28 (48.3) | 0.079 | 47 (81.0) | 11 (19.0) | 0.033* | 35 (60.3) | 23(39.7) | 0.103 |
| ≥5.0 cm (n = 45) | 31(68.9) | 14(31.1) | 28(62.2) | 17 (37.8) | 34(75.6) | 11 (24.4) | |||
| WHO grade | |||||||||
| I (n = 16) | 11 (68.8) | 5(31.2) | 13 (81.3) | 3 (18.7) | 11 (68.8) | 5 (31.2) | |||
| II(n = 32) | 21 (65.6) | 11 (34.4) | 28 (87.5) | 4 (12.5) | 19 (59.4) | 13(40.6) | |||
| III(n = 39) | 23 (59.0) | 16 (41.0) | 0.234 | 26 (66.7) | 13 (33.3) | 0.029* | 28 (71.8) | 11(28.2) | 0.731 |
| IV (n = 16) | 6 (37.5) | 10 (62.5) | 8(50.0) | 8 (50.0) | 11(68.8) | 5 (31.2) | |||
| Survival status | |||||||||
| Replase free survival (n = 36) | 27 (75.0) | 9 (25.0) | 29(80.6) | 7 (19.4) | 30(83.3) | 6 (16.7) | |||
| Replase (n = 25) | 10 (40.0) | 15 (60.0) | 0.022* | 15(60.0) | 10 (40.0) | 0.203 | 13(52.0) | 12 (48.0) | 0.025* |
| Death (n = 42) | 24 (57.1) | 18 (42.9) | 31(73.8) | 11 (26.2) | 26(61.9) | 16 (38.1) | |||
Abbreviations: Statistical analysis was performed using the Chi-squared test.
*Statistically significant (p < 0.05).
1The average age of all subjects was 42.3 years;
2The average tumor size of all subjects was 5.0cm. n, Number of cases; WHO, World Health Organization.
# N-: Other immunophenotype of HSP10 and c-PARP; P+: High expression of HSP10 and low expression of c-PARP.