Table 3. Associations between DNAm, genotypes at meSNPs, and treatment response.
| rsID | cg | Genotype (n) | beta at T1 (SD) | %Poor responders | Genetic association (p value) | Chr | location | MA (%) (ED) |
MA (%) (UCSC hg19) |
Putative function |
|---|---|---|---|---|---|---|---|---|---|---|
| rs12282251 | cg16827215 | CC (20) | 0.76 (0.06) | 75% | 0.003 | 11 | 11292635 | T (0.20) | T (0.18) | 3’ UTR |
| CT (13) | 0.43 (0.03) | 23% | ||||||||
| rs34756202 | cg01882774 | CC (17) | 0.83 (0.03) | 35% | 0.11 | 14 | 94491763 | T (0.30) | T (0.26) | Intron/upstream |
| CT (12) | 0.50 (0.10) | 83% | ||||||||
| TT (4) | 0.07 (0.03) | 50% | ||||||||
| rs7933565 | cg19680693 | GG (12) | 0.83 (0.04) | 42% | 0.10 | 11 | 94111808 | A (0.45) | A (0.53) | 3’ UTR |
| GA (12) | 0.52 (0.07) | 50% | ||||||||
| AA (9) | 0.11 (0.05) | 78% | ||||||||
| rs66630638 | cg08891829 | GG (22) | 0.93 (0.01) | 36% | 0.002 | 4 | 56231728 | A (0.16) | A (0.14) | intron |
| AG (10) | 0.52 (0.05) | 90% | ||||||||
| AA (1) | 0.04 (-) | 100% | ||||||||
| rs73006518 | cg22843488 | CC (22) | 0.90 (0.02) | 41% | 0.015 | 3 | 151017685 | T (0.19) | T (0.06) | intron |
| CT (9) | 0.67 (0.10) | 78% | ||||||||
| TT (2) | 0.13 (0.02) | 100% | ||||||||
| rs76828276 | cg05187322 | CC (24) | 0.90 (0.02) | 42% | 0.010 | 17 | 78152328 | T (0.12) | T (0.07) | 5’ UTR |
| CT (9) | 0.49 (0.04) | 89% |
Note: Minor allele and frequencies from current ED study and UCSC (hg19) were listed. For the genetic association tests, additive models were used. No effects of age, sex or race on the responder status were detected.