Table 1.

Screening of the Transient Directing Group^a,^b

^aStandard conditions: 0.2 mmol of 1, 2.0 equiv. of methyl 4-iodobenzoate, 10 mol% of Pd(OAc)₂, 30 mol% of TDG, 1.0 equiv. of AgTFA, 2.0 equiv. of AgOAc, 1.5 mL of HFIP, 0.5 mL of acetic acid, 120 °C, under air, 48 h.

^bThe yield was determined by ¹H NMR analysis of the crude product using CH₂Br₂ as the internal standard.

^c3.0 equiv. of AgTFA was employed as the additive.

^dAr_F = 4-(CF₃)C₆F₄.

^eReaction was conducted for 72 h.