Table 3.
Concordance between albuminuria and declined renal function
| Reduced renal function
|
eGFR by adjusted CG (n, %)
|
eGFR by BIS1
|
eGFR by mMDRD
|
eGFR by MDRD
|
eGFR by CKD-EPI
|
eGFR by EPI -Asian
|
eGFR by Ruijin
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Albuminuria | No 15,445 (71.1%) |
Yes 6,278 (28.9%) |
No 13,228 (60.9) |
Yes 8,495 (39.1) |
No 19,907 (91.6%) | Yes 1,816 (8.4%) | No 19,165 (88.2%) | Yes 2,558 (11.8%) | No 18,613 (85.7%) |
Yes 3,110 (14.3%) |
No 19,221 (88.5%) |
Yes 2,502 (11.5%) |
No 18,954 (87.3%) | Yes 2,769 (12.7%) |
| Normal, N (%) | 10,605 (48.8%) |
3,481 (16.0%) |
9,100 (41.9%) |
4,986 (23.0%) |
13,313 (61.3%) |
773 (3.6%) | 12,909 (59.4%) |
1,177 (5.4%) | 12,596 (58.0%) |
1,490 (6.9%) |
12,948 (59.6%) |
1,138 (5.2%) |
12,793 (58.9%) |
1,293 (6.0%) |
| Microalbuminuria, N (%) | 4,423 (20.4%) |
2,294 (10.6%) |
3,783 (17.4%) |
2,934 (13.5%) |
5,969 (27.5%) |
748 (3.4%) | 5,675 (26.1%) |
1,042 (4.8%) | 5,459 (25.1%) |
1,258 (5.8%) |
5,678 (26.1%) |
1,039 (4.8%) |
5,587 (25.7%) |
1,130 (5.2%) |
| Macroalbuminuria, N (%) | 417 (1.9%) |
503 (2.3%) |
345 (1.6%) |
575 (2.6%) |
625 (2.9%) |
295 (1.4%) |
581 (2.7%) |
339 (1.6%) |
558 (2.6%) |
362 (1.7%) |
594 (2.7%) |
326 (1.5%) |
574 (2.6%) |
346 (1.6%) |
| Micro + macroalmuminuria, N (%) | 4,840 (22.3%) |
2,797 (12.9%) |
4,128 (19.0%) |
3,509 (16.2%) |
6,594 (30.4%) |
1,043 (4.8%) |
6,256 (28.8%) |
1,381 (6.4%) |
6,017 (27.7%) |
1,620 (7.5%) |
6,272 (28.8%) |
1,365 (6.3%) |
6,161 (28.3%) |
1,476 (6.8%) |
| Kappa (95% CI) |
0.124 (0.111–0.137) |
0.103 (0.089–0.116) |
0.099 (0.089–0.108) |
0.115 (0.103–0.127) |
0.123 (0.111–0.135) |
0.116 (0.104–0.128) |
0.119 (0.107–0.131) |
|||||||
| ICC (95% CI) |
0.223 (0.202–0.243) |
0.187 (0.165–0.208) |
0.218 (0.197–0.238) |
0.236 (0.215–0.256) |
0.243 (0.223–0.263) |
0.238 (0.218–0.258) |
0.240 (0.220–0.260) |
|||||||
Note: Microalbuminuria: ACR 30 to <300 mg/g, macroalbuminuria: ACR ≥300 mg/g, reduced renal function: eGFR <60 mL/min/1.73 m2.
Abbreviations: BIS1, Berlin initiative study 1 equation; 95% CI, 95% confidence interval; ACR, albumin to creatinine ratio; CG, Cockcroft–Gault equation; CKD-EPI, chronic kidney disease epidemiology collaboration; CKD-EPI-Asia, CKD-EPI equation in Asians; eGFR, estimated glomerular filtration rate; ICC, intraclass correlation coefficient; MDRD, modification of diet in renal disease equation; mMDRD, MDRD modified for Chinese equation; Ruijin, Chinese Ruijin equation.