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. Author manuscript; available in PMC: 2019 Mar 15.
Published in final edited form as: Behav Brain Res. 2017 Apr 13;340:195–204. doi: 10.1016/j.bbr.2017.04.017

Figure 4. Treatment with memantine partially restores the LTP deficit after rmTBI.

Figure 4

(A) The LTP responses induced by HFS in M1 slices. LTP magnitude (fEPSP slope change 30min after HFS relative to baseline) was attenuated in the vehicle treated mice (Veh: 110.4 ± 0.8% of baseline; n=9, p<0.001) as compared to sham (183.6 ± 1.7% of baseline; n=8, p<0.001). In the memantine (MEM) treated group, this LTP deficit was partially recovered (132.6 ± 2.4% of baseline; n=7, p<0.001). (B) Statistic analysis of the fEPSP slopes changes averaged from the last 10-min’s (45–55min) recording of each group [F(2,30)=786.3, p<0.001 by one-way ANOVA]: ***p<0.001 indicates post hoc test between two means as indicated in the graph. ###p<0.001 indicates paired t-test between fESPS slope changes and individual baseline (initial 10-min’s recording). n = 8/group