Table 2.

Accuracy of the different scores across criteria for suspicion of infection, with cut-offs matched to the sensitivity of qSOFA ≥1

Algorithm	Score	Sensitivity	Specificity	PPV	NPV
SOFA ≥1	Any culture	68%	45%	15%	91%
	Blood culture	69%	46%	18%	89%
	Any culture + abx	68%	53%	23%	89%
	Blood culture + abx	69%	52%	25%	88%
	Any culture + 4d abx	67%	53%	28%	85%
	Blood culture + 4d abx	69%	51%	30%	84%
SIRS ≥2	Any culture	66%	50%	15%	91%
	Blood culture	68%	46%	18%	89%
	Any culture + abx	66%	52%	22%	88%
	Blood culture + abx	68%	49%	23%	87%
	Any culture + 4d abx	66%	51%	29%	83%
	Blood culture + 4d abx	69%	47%	25%	84%
qSOFA ≥1	Any culture	69%	52%	17%	92%
	Blood culture	71%	51%	20%	91%
	Any culture + abx	69%	57%	25%	90%
	Blood culture + abx	72%	55%	27%	90%
	Any culture + 4d abx	71%	56%	33%	86%
	Blood culture + 4d abx	73%	54%	30%	88%
MEWS ≥3	Any culture	69%	57%	18%	93%
	Blood culture	72%	51%	20%	91%
	Any culture + abx	69%	56%	24%	90%
	Blood culture + abx	72%	52%	26%	89%
	Any culture + 4d abx	71%	55%	32%	86%
	Blood culture + 4d abx	74%	51%	29%	88%
NEWS ≥5	Any culture	63%	64%	19%	93%
	Blood culture	66%	62%	23%	91%
	Any culture + abx	64%	67%	28%	90%
	Blood culture + abx	67%	65%	31%	90%
	Any culture + 4d abx	65%	67%	32%	86%
	Blood culture + 4d abx	68%	64%	34%	88%
eCART ≥10	Any culture	69%	64%	21%	94%
	Blood culture	71%	61%	24%	92%
	Any culture + abx	69%	65%	29%	91%
	Blood culture + abx	72%	62%	30%	91%
	Any culture + 4d abx	71%	64%	38%	88%
	Blood culture + 4d abx	73%	61%	34%	89%