Table 3.

Accuracy of the different scores across criteria for suspicion of infection, with cut-offs matched to the sensitivity of qSOFA ≥2

Algorithm	Score	Sensitivity	Specificity	PPV	NPV
SOFA ≥4	Any culture	20%	88%	19%	89%
	Blood culture	22%	87%	23%	86%
	Any culture + abx	19%	90%	28%	84%
	Blood culture + abx	21%	89%	31%	83%
	Any culture + 4d abx	19%	89%	32%	80%
	Blood culture + 4d abx	22%	88%	36%	79%
qSOFA ≥2	Any culture	18%	92%	24%	89%
	Blood culture	21%	91%	29%	87%
	Any culture + abx	19%	94%	39%	85%
	Blood culture + abx	21%	93%	41%	84%
	Any culture + 4d abx	21%	93%	48%	79%
	Blood culture + 4d abx	23%	92%	44%	81%
MEWS ≥6	Any culture	17%	96%	37%	89%
	Blood culture	19%	94%	36%	87%
	Any culture + abx	18%	95%	42%	85%
	Blood culture + abx	20%	94%	43%	84%
	Any culture + 4d abx	19%	95%	54%	79%
	Blood culture + 4d abx	21%	93%	45%	81%
NEWS ≥9	Any culture	20%	94%	31%	90%
	Blood culture	22%	94%	39%	87%
	Any culture + abx	21%	95%	46%	85%
	Blood culture + abx	22%	94%	46%	84%
	Any culture + 4d abx	23%	95%	58%	80%
	Blood culture + 4d abx	24%	94%	52%	82%
eCART ≥25	Any culture	25%	94%	36%	90%
	Blood culture	28%	93%	41%	88%
	Any culture + abx	27%	94%	48%	86%
	Blood culture + abx	28%	93%	48%	85%
	Any culture + 4d abx	29%	93%	56%	81%
	Blood culture + 4d abx	30%	92%	51%	83%