Figure 6.

Rigosertib Binds to Tubulin in the Colchicine Site

(A) Overall view of the αβ-tubulin-rigosertib complex. The α- and β-tubulin subunits are shown in dark and light gray ribbon representation, respectively. Bound rigosertib (light magenta) and GTP (orange) are shown in sphere representation.

(B) Close-up view of the interactions between rigosertib (magenta sticks) and tubulin. Interacting residues are shown as gray sticks. Hydrogen bonds are represented with black dashed lines. For clarity, not all interacting residues are displayed. Secondary structure elements are labeled in blue.

(C) Superimposition of the tubulin-rigosertib (magenta) and tubulin-colchicine (PDB: 4O2B; green) complex structures, shown as in (B).

See also Figure S5.