Figure 9.

Cell function and cell response trends. A: Differential selection leads to enrichment and depletion of genes defining specific cell function and cell response. A focused cell function analysis was performed. A Boolean search for specific text strings was used to mine the NCBI gene database. We specifically mined for genes pertaining to the following categories (inflammation, apoptosis, cytokine, innate immune, receptor, growth factor, stress response, and transcription factor). Genes related to each text string were mined, and only rat genes were retrieved. Each gene list retrieved was aligned against a non-redundant gene list representing the microarray used, and this, in turn, was aligned to the differential comparison output data. From these alignments, we extracted the information needed to set up and perform a Fisher’s exact test for each functional category. P>0.05 indicates the absence of significant enrichment. –Log (p value) was plotted so changes in a single unit represent, a ten-fold difference. The blue line just above the value of 1 indicates the equivalent cut-off point for a p value of 0.05. B: Summary of the differential expression status for retinal cell associated gene markers and G-protein coupled protein associated gene markers.