Table 2.

Hormonal and metabolic parameters of PCOS sons (PCOSs) and control sons (Cs) at the different Tanner stages analysed.

	Tanner I			Tanner II–III			Tanner IV–V
	Cs	PCOSs	P value	Cs	PCOSs	P value	Cs	PCOSs	P value
n	20	23		31	26		33	20
SHBG (nmol/L)	56 (37–86)	47 (35–67)	0.274	46 (31–69)	50 (30–72)	0.999	21 (16–30)	21 (17–28)	0.953
LH (IU/L)	0.07 (0.04–0.19)	0.13 (0.05–0.91)	0.295	0.75 (0.14–3.0)	0.23 (0.05–1.8)	0.543	5.52 (2.9–9.8)	6.02 (3.72–7.04)	0.785
FSH (IU/L)	0.29 (0.07–0.74)	0.47 (0.22–0.74)	0.382	0.37 (0.12–0.84)	0.98 (0.29–2.22)	0.019	0.71 (0.34–1.77)	0.62 (0.33–2.36)	0.873
Testosterone (ng/mL)	0.09 (0.06–0.18)	0.14 (0.09–0.21)	0.103	0.23 (0.12–0.89)	0.32 (0.15–1.22)	0.319	3.68 (2.5–4.52)	3.8 (3.07–6.16)	0.206
Androstenedione (ng/mL)	0.3 (0.18–0.62)	0.52 (0.34–0.67)	0.154	0.53 (0.3–0.88)	0.69 (0.62–1.1)	0.038	1.23 (0.87–1.62)	1.38 (1.13–1.87)	0.109
17 OH progesterone (ng/mL)	0.61 (0.47–1.2)	0.68 (0.43–0.88)	0.801	0.69 (0.5–1.19)	0.66 (0.55–0.95)	0.976	1.33 (0.99–2.04)	1.56 (1.33–2.48)	0.085
FAI	0.7 (0.3–1.1)	1.0 (0.7–1.7)	0.098	2.4 (0.9–5.4)	2.9 (1.4–12.3)	0.295	48.9 (28.1–94.6)	62.9 (43.5–88.2)	0.533
AMH (mM)	529 (434–781)	549 (458–726)	0.634	412 (200–529)	441 (155–516)	0.920	70 (46–127)	71 (41–132)	0.772
Glucose basal (mg/dL)	80 (77.2–85)	84 (78–89)	0.288	84 (76–90)	87 (81–94)	0.117	83 (76–90)	83 (78–86)	0.809
Glucose 30 min (mg/mL)	108 (88–146)	110 (94–129)	0.798	126 (114–147)	114 (104–144)	0.092	127 (102–135)	121 (103–134)	0.545
Glucose 60 min (mg/mL)	94 (81–110)	101 (82–109)	0.361	98 (84–123)	108 (91–127)	0.189	96 (89–113)	106 (83–114)	0.880
Glucose 120 min (mg/mL)	91 (81–101.3)	96 (86–113)	0.172	96 (87–114)	102 (93–113)	0.353	97 (83–106)	95 (82–107)	0.952
Insulin basal (µIU/mL)	8 (5–12)	7 (5–12)	0.722	10 (7–14)	9 (7–13)	0.950	13 (11–17)	13 (9–17)	0.816
Insulin 30 min (µIU/mL)	41 (34–120)	48 (26–72)	0.622	65 (32–132)	58 (39–118)	0.970	100 (64–179)	104 (49–154)	0.570
Insulin 60 min (µIU/mL)	35 (15–65)	39 (25–48)	0.565	37 (20–76)	45 (28–81)	0.245	67 (39–96)	59 (34–117)	0.841
Insulin 120 min (µIU/mL)	28 (19–49)	26 (12–39)	0.651	34 (19–70)	42 (24–83)	0.569	42 (26–80)	44 (23–65)	0.743
HOMA–IR	1.5 (1.1–2.6)	1.6 (1.0–2.5)	0.918	2.0 (1.5–2.9)	1.9 (1.5–2.7)	0.902	2.7 (2–3.6)	2.6 (1.7–3.5)	0.719
ISI composite	7.2 (4.4–10.8)	7.0 (5.4–8.8)	0.889	4.9 (3.4–8.7)	5.3 (3.6–7.7)	0.777	4.5 (2.7–6.0)	4.3 (3.0–6.1)	0.823
Tryglicerides (mg/dL)	108 (86–132)	104 (81–137)	0.616	106 (82–141)	126 (89–151)	0.345	124 (87–141)	123 (91–149)	0.809
Total cholesterol (mg/dL)	141 (133–164)	155 (129–176)	0.355	140 (130–159)	164 (142–179)	0.006	120 (106–140)	140 (118–166)	0.028
HDL (mg/dL)	44 (39–53)	40 (37–50)	0.115	42 (37–45)	42 (38–52)	0.670	38 (32–43)	39 (34–44)	0.816
LDL (mg/dL)	74 (57–82)	89 (70–108)	0.085	80 (58–93)	93 (79–104)	0.015	55 (45–77)	78 (58 –101)	0.014

Data are median and interquartile range.