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. 2017 Oct 13;8:932. doi: 10.1038/s41467-017-01381-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — CCDC88B expression in inflamed colons from patients with IBD. a CCDC88B mRNA expression in colon tissue samples extracted from surgical specimens of patients with Crohn’s Disease (CD, n = 11), Ulcerative colitis (UC, n = 46) or normal control (NL, n = 73). Data represent expression of CCDC88B relative to the ribosomal protein L32 (mean±SEM; **P < 0.01, ***P < 0.001; two-tailed Student’s t-test). b Immunoblot analysis of CCDC88B and β-ACTIN performed on colonic tissue extracts obtained from surgical specimens of patients with CD (n = 4), UC (n = 4) or NL controls (n = 4). Each lane denotes an individual patient sample. Densitometric quantification of CCDC88B and β-actin immunoblots. Bar graphs represent normalized relative density of each lane (n = 4 patient samples). c IL-8 mRNA expression in colon tissues samples from CD (n = 69), UC (n = 7) and NL (n = 38). Data represent expression of IL8 relative to the ribosomal protein L32 (mean±SEM; **P < 0.01, ***P < 0.001; two-tailed Student’s t-test). d, e Immunofluorescence staining of CCDC88B, CD4 and CD68 in colon tissue sections from patients with CD, UC, or NL controls (CCDC88B, red; nuclei blue staining with Hoechst). Isotype control staining for each section is shown. Scale bars, 100 µm and 10 µm