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. 2017 Oct 13;7:13133. doi: 10.1038/s41598-017-12956-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of AIE, and Gabapentin Slice Pre-Incubation on RO25–6981-induced Inhibition of NMDA Receptor-Mediated Currents. A. Representative eEPSCs recorded in cells from control (AIW) animals (upper panels) and AIE-exposed (AIE) animals (lower panels) after slices were pre-incubated in normal aCSF (Control - left panels) or aCSF containing 30 μM gabapentin (Gabapentin - right panels). RO25–6981 consistently reduced current amplitude, but did so more efficaciously in cells from slices that were not pre-incubated in gabapentin. B. Mean (±SEM) percent reduction of NMDA receptor-mediated current amplitudes by RO25–6981, recorded in CA1 pyramidal cells from AIE-exposed animals (closed circles) compared to controls (open circles), after pre-incubation in aCSF (Control) or aCSF containing 30 μM gabapentin (Gabapentin). RO25–6981 induced inhibition was greater after AIE than after AIW when slices were pre-incubated in aCSF [right panel (Control, #): simple main effect, p = 0.02]. Conversely, RO25–6981 induced inhibition was greater in AIW than in AIE when slices were pre-incubated in aCSF+ gabapentin [right panel (Gabapentin, ‡): simple main effect, p = 0.006]. Moreover, gabapentin pre-incubation significantly attenuated RO25–6981-induced inhibition of NMDA current amplitudes in slices from AIE animals [right panel (closed circles,★): simple main effect, p = 0.001] but not in those from AIW animals [right panel (open circles, ☆), simple main effect, p = 0.28].