Fig. 8.

Model for the role of NatD in EMT. In human lung cancer cells, when NatD levels are low, CK2α phosphorylates histone H4S1, which silences Slug expression, retaining tumor cells in the epithelial state. When NatD levels are high, NatD acetylates histone H4 serine 1 (S1), which blocks CK2α-mediated S1 phosphorylation, and allows arginine 3 (R3) methylation and lysine 5 (K5) acetylation to activate Slug gene expression, promoting EMT to generate mesenchymal tumor cells, which increases cancer cell invasion and metastasis. PRMT protein arginine methyltransferase, HAT histone acetyltransferase