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. 2017 Oct 13;7:13138. doi: 10.1038/s41598-017-13744-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Cell metabolic activity on rat cardiomyoblasts H9C2 treated with control polymers and hollow spheres. (A) Linear dithiolPEG, linear PEG2000 after 24 hours of exposure and (B) the dithiolPEG chemical structure; alamarBlue® assay was carried out on the dithiolPEG (orange), PEG2000 (blue), and untreated cells (green) (n=3, p<0.05). Cell metabolic activity on the collagen-dithiolPEG hollow spheres (C) and collagen-4armPEG hollow spheres (D) (n=3, p<0.05). Polystyrene (green) and untreated cells (orange) were used as controls