Table 2.
Allele and genotype distribution of the ETS1 gene markers in IIM patients and controls.
| SNPs | Groups | Allele (%) | OR (95%CI) | P | Pc | Genotype (%) | χ2 | P | Pc | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| rs6590330 | A | G | AA | GA | GG | |||||||
| DM | 490(37.5) | 818(62.5) | 1.19(1.04–1.38) | 0.011 | 0.033 | 85(13.0) | 320(48.9) | 249(38.1) | 6.80 | 0.033 | 0.099 | |
| PM | 271(37.3) | 455(62.7) | 1.19(1.00–1.41) | 0.047 | 0.141 | 40(11.0) | 191(52.6) | 132(36.4) | 7.12 | 0.028 | 0.084 | |
| IIM | 761(37.4) | 1273(62.6) | 1.19(1.06–1.35) | 4.2 × 10−3 | 0.013 | 125(12.3) | 511(50.2) | 381(37.5) | 10.0 | 6.7 × 10−3 | 0.020 | |
| Controls | 854(33.4) | 1706(66.6) | 137(10.7) | 580(45.3) | 563(44.0) | |||||||
| rs7117932 | T | C | TT | TC | CC | |||||||
| DM | 388(29.7) | 920(70.3) | 1.26(1.08–1.46) | 2.0 × 10−3 | 6.0 × 10−3 | 56(8.6) | 276(42.2) | 322(49.2) | 9.30 | 9.5 × 10−3 | 0.029 | |
| PM | 200(27.5) | 526(72.5) | 1.13(0.94–1.36) | 0.193 | 0.579 | 21(5.8) | 158(43.5) | 184(50.7) | 5.32 | 0.070 | 0.210 | |
| IIM | 588(28.9) | 1446(71.1) | 1.21(1.06–1.38) | 4.3 × 10−3 | 0.013 | 77(7.6) | 434(42.7) | 506(49.7) | 10.1 | 6.4 × 10−3 | 0.019 | |
| Controls | 644(25.2) | 1916(74.8) | 86(6.7) | 472(36.9) | 722(56.4) | |||||||
| rs4937362 | C | T | CC | TC | TT | |||||||
| DM | 395(30.4) | 905(69.6) | 0.91(0.79–1.05) | 0.190 | 0.570 | 63(9.7) | 269(41.4) | 318(48.9) | 1.73 | 0.422 | NS | |
| PM | 208(28.8) | 514(71.2) | 0.84(0.70–1.00) | 0.062 | 0.186 | 32(8.9) | 144(39.9) | 185(51.2) | 3.36 | 0.187 | 0.561 | |
| IIM | 603(29.8) | 1419(70.2) | 0.79(0.68–0.91) | 0.056 | 0.168 | 95(9.4) | 413(40.9) | 503(49.7) | 3.60 | 0.165 | 0.495 | |
| Controls | 831(32.5) | 1729(67.5) | 145(11.3) | 541(42.3) | 594(46.4) | |||||||
Bold values are statistically significant (P < 0.05) (corrected for multiple comparisons by the Bonferroni adjustment test).
PM: polymyositis; DM: dermatomyositis; IIM: idiopathic inflammatory myopathies; OR: odds ratio; CI: confidence interval; χ2: Chi-square test; Pc: P value corrected by Bonferroni method; NS: not significant.