Table 4.
Association between the SNPs and IIM with ILD.
| Disease | Group | rs6590330 | rs7117932 | rs4937362 | |||
|---|---|---|---|---|---|---|---|
| Pc | OR (95%CI) | Pc | OR (95%CI) | Pc | OR (95%CI) | ||
| DM | P vs. N | NS | 1.10(0.87–1.38) | NS | 1.11(0.87–1.41) | NS | 1.10(0.87–1.40) |
| P vs. C | 0.031 | 1.24(1.05–1.47) | 8.90 × 10 −3 | 1.31(1.10–1.56) | NS | 0.94(0.79–1.12) | |
| N vs. C | 0.63 | 1.13(0.93–1.38) | 0.35 | 1.18(0.96–1.46) | 0.41 | 0.86(0.70–1.05) | |
| PM | P vs. N | NS | 0.90(0.66–1.21) | NS | 0.99(0.71–1.37) | 0.91 | 0.85(0.61–1.17) |
| P vs. C | 0.82 | 1.13(0.91–1.41) | NS | 1.13(0.89–1.43) | 0.16 | 0.78(0.61–0.99) | |
| N vs. C | 0.16 | 1.26(1.00–1.59) | 0.95 | 1.14(0.88–1.47) | NS | 0.92(0.72–1.18) | |
| IIM | P vs. N | NS | 1.02(0.85–1.22) | NS | 1.07(0.88–1.30) | NS | 1.00(0.83–1.22) |
| P vs. C | 0.034 | 1.20(1.04–1.39) | 0.016 | 1.24(1.07–1.45) | 0.35 | 0.89(0.76–1.03) | |
| N vs. C | 0.13 | 1.18(1.00–1.39) | 0.26 | 1.16(0.98–1.38) | 0.41 | 0.88(0.74–1.04) | |
Bold values are statistically significant (P < 0.05) (corrected for multiple comparisons by the Bonferroni adjustment test). DM: dematomyositis; PM: polymyositis; IIM: idiopathic inflammatory myopathies; ILD: interstitial lung disease; Group P: patients with ILD; Group N: patients without ILD; Group C: Healthy controls; Pc: P value corrected by Bonferroni method. Group P (DM: n = 390; PM: n = 195; IIM: n = 585); Group N (DM: n = 264; PM: n = 168; IIM: n = 432); Group C (n = 1280).