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. 2016 Feb 5;1(2):130–136. doi: 10.1016/j.synbio.2015.12.001

Fig. 2.

Fig. 2

Hybrid polyketide-nonribosomal peptide gene clusters of Legionella pneumophila targeted for mutagenesis. PRISM identified three hybrid PKS-NRPS gene clusters in the genome of L. pneumophila LP02, roughly defined as lpg1936-lpg1943, lpg2177-lpg2186, and lpg2225-lpg2232. Ketosynthases in each gene cluster were insertionally inactivated by insertion of a kanamycin resistance gene, disrupting expression of lpg1939, lpg2186, and lpg2228 (red).