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A considerable fraction of microbial peptides displaying sequence homology with human proteins demonstrates strong MHC class II-binding. Bar diagram depicts the number of strong binders (IC50 ≤ 50) and weak binders (50 < IC50 ≤ 500) utilizing NetMHCII2.2 among the total binders from microbial antigens that shared similarity with human proteins from the identified data set. SB, strong binders (red); WB, weak binders (blue); mm, molecular mimicry; mp, microbial peptides.
