Table 2.

Broad spectrum synergistic antifungal activity of BEA.

Strain	MIC (µg/ml)b			FICIc	MIC (µg/ml)b		FICIc
	BEA[a]	KTC[a]	KTC[c]		ICZ[a]	ICZ[c]
Candida albicans SC5314	8	0.008	0.002	0.5	0.032	0.004	0.375
Candida tropicalisa	16	1.6–3.2	<0.064	<0.145	0.032	0.008	0.5
Candida kruseia	>32	0.8–1.6	0.025	<0.28	0.5	0.064	0.378
Candida parapsilosis ATCC14054	16	0.025	<0.0064	<0.5	0.25	0.004	0.266

^aClinical isolates;

^b[a], alone, [c], combination with 1/4MIC of BEA;

^cFICI = (MIC_{drug A in combination}/MIC_{drug A alone}) + (MIC_{drug B in combination}/MIC_{drug B alone}), (FICI > 4: Antagonism; FICI < 0.5: Synergy; 0.5 < FICI < 4: Additive).