FIG 1.

BA71ΔCD2 is genetically stable in COS-1 cells. (A) Dot plot representing the conservation of the sequence of BA71ΔCD2 after passages in COS-1 cells compared with the BA71 parental strain. The continuous line of dots with a slope of 1 represents the undisturbed segment of conservation, disrupted only in the region where the EP402R gene was deleted. (B) Detailed table showing the differences observed between the genomes. (C) Depth of the genome sequence obtained. The partial deletion of the EP402R gene and the two genes flanking the region are schematically represented below the plot.