FIG 6.

Cross-protection correlates with the ability of BA71ΔCD2 to induce cross-reactive CD8⁺ T cells. The levels of ASFV-specific antibodies (gray bars, left y axis) and T cells (▲, right y axis) found in the blood of individual BA71ΔCD2-inoculated pigs just before E75 challenge are shown (A). The percentage of CD8⁺ T cells specifically proliferating in response to in vitro BA71 or E75 stimulation is also shown (B). The histogram displays the results obtained from a BA71ΔCD2-inoculated pig that survived E75 challenge, using PBMCs obtained just before E75 challenge. *, ≥300 IFN-γ secreting cells; +, BA71ΔCD2-inoculated pigs not protected against E75 lethal challenge.