FIG 2.

HPV58 lineage- and sublineage-specific nucleotide and amino acid changes across the complete genome. The x axis shows HPV58 gene/region positions, aligned according to the sublineage in the phylogenetic tree on the y axis. Lineage- and sublineage-specific SNPs were determined based on a global alignment of 90 complete genomes and color-coded as shown at the top. Amino acid changes within the E2/E4 region are changes observed in E2. SNPs were cumulative for the underlined lineages traversed from deepest node out to finer subline branches (dotted lines).