Figure 2.

Transient receptor potential mucolipin-1 (TRPML1) was upregulated, mTOR/S6K signaling pathway was activated, and markers of the autophagy–lysosomal system were downregulated after curcumin use in amyloid-β1-42 (Aβ1-42)-treated HT-22 cells. (A) The protein level of TRPML1 was downregulated after Aβ1-42 treatment as compared to the control, curcumin reversed this result. (B) Curcumin use upregulated Aβ1-42-inhibited protein levels of p-mTOR and p-S6K. (C) Curcumin use downregulated Aβ1-42-induced protein levels of Beclin, LC3, and LAMP-1. *p < 0.05 compared to the control group and ^#p < 0.05 compared to the Aβ1-42 group.