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. 2017 Oct 9;8:531. doi: 10.3389/fneur.2017.00531

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Copyright © 2017 Zhang, Fang, Cheng, Lian, Xu, Zeng and Zhu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Knockdown of PI(3,5)P2 or transient receptor potential mucolipin-1 (TRPML1) inhibited mTOR/S6K signaling pathway and increased the protein levels of markers of the autophagy–lysosomal system after curcumin use in APP/PS1 mice. (A) The protein level of TRPML1 in APP/PS1 + CUR + Sh-TRPML1 group was decreased, and PI(3,5)P2 knockdown in APP/PS1 transgenic mice with curcumin treatment decreased the protein level of TRPML1 as compared to the APP/PS1 + CUR group. (B) Knockdown of PI(3,5)P2 or TRPML1 decreased the protein levels of p-mTOR and p-S6K after curcumin use in APP/PS1 mice. (C) Knockdown of PI(3,5)P2 or TRPML1 increased the protein levels of Beclin, LC3, and LAMP-1 after curcumin use in APP/PS1 mice. *p < 0.05 compared to the control. ^#p < 0.05 compared to the APP/PS1 group. ^&p < 0.05 compared to the APP/PS1 + CUR group.