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. 2017 Oct 9;8:531. doi: 10.3389/fneur.2017.00531

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Copyright © 2017 Zhang, Fang, Cheng, Lian, Xu, Zeng and Zhu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Knockdown of PI(3,5)P2 or transient receptor potential mucolipin-1 (TRPML1) reversed the protective role of curcumin on memory and recognition impairments in mice with APP/PS1 transgenes. Knockdown of PI(3,5)P2 or TRPML1 in mice with APP/PS1 transgenes after curcumin treatment caused significant inductions in escape latency (A), travel length (B), and times cross the platform (C), but caused a significant reduction recognition index (D) in comparison with APP/PS1 + CUR group. *p < 0.05 compared to the control. ^#p < 0.05 compared to the APP/PS1 group. ^&p < 0.05 compared to the APP/PS1 + CUR group.