Table 1.
Characteristics of the individuals in each EWAS model
| DNA methylation (outcome) | Asthma/wheeze (exposure) | Status | N | Sex [male] N (%) | Maternal age [months] mean (SD) | Maternal smoking [never] N (%) | Parity [nulliparous] N (%) | Maternal education [O-level or lower] N (%) |
|---|---|---|---|---|---|---|---|---|
| 7.5 years | Current asthma at 7.5 years | Cases | 149 | 88 (59%) | 369 (53.4) | 124 (83%) | 62 (42%) | 68 (46%) |
| Controls | 632 | 308 (49%) | 364 (51.7) | 560 (89%) | 286 (45%) | 306 (48%) | ||
| Current wheeze at 7.5 years | Cases | 111 | 66 (60%) | 372 (55) | 94 (85%) | 43 (39%) | 520 (45%) | |
| Controls | 742 | 366 (49%) | 361 (52) | 650 (88%) | 348 (47%) | 362 (49%) | ||
| 16.5 years | Ever asthma at 16.5 years | Cases | 194 | 102 (53%) | 363 (53) | 163 (84%) | 97 (50%) | 87 (45%) |
| Controls | 554 | 264 (48%) | 364 (51) | 503 (91%) | 258 (47%) | 262 (47%) | ||
| Ever wheeze at 16.5 years | Cases | 204 | 108 (53%) | 367 (49) | 173 (85%) | 102 (50%) | 82 (40%) | |
| Controls | 554 | 264 (48%) | 363 (52) | 503 (91%) | 261 (47%) | 271 (49%) | ||
| Current asthma at 16.5 years | Cases | 184 | 73 (40%) | 362 (51.6) | 150 (82%) | 89 (48%) | 89 (46%) | |
| Controls | 427 | 200 (47%) | 364 (51.7) | 384 (90%) | 204 (48%) | 198 (46%) |